The three‐dimensional structure of DNA depends subtly on its sequence, and this property is used by the proteins that regulate gene expression to locate their target sequences. Despite the large body of experimental data that has been accumulated on the relationship between sequence and DNA structure, we still do not fully understand the molecular basis for these properties, nor can we predict a three‐dimensional structure from a given sequence. We have been using computer modelling to tackle these problems. Some of (...) our results and the implications for understanding the biological role of key sequences are discussed here. (shrink)

The three‐dimensional structure of DNA depends subtly on its sequence, and this property is used by the proteins that regulate gene expression to locate their target sequences. Despite the large body of experimental data that has been accumulated on the relationship between sequence and DNA structure, we still do not fully understand the molecular basis for these properties, nor can we predict a three‐dimensional structure from a given sequence. We have been using computer modelling to tackle these problems. Some of (...) our results and the implications for understanding the biological role of key sequences are discussed here. (shrink)

Thirty-two vegans were interviewed in order to examine the reasons for becoming vegan, the sustaining motivation to persist, the interpersonal and intrapersonal impact of the diet and associated practices, and the vegans’ assessment of omnivores’ eating practices. Interviews were analyzed using a model that diagrams the process of becoming vegan provided by McDonald . Participants reported strained professional and personal relationships as a result of their diet and beliefs. Vegan diets were associated with an increase in physical, eudaemonic, and spiritual (...) well-being. (shrink)

Ecological communities are seldom, if ever, biological individuals. They lack causal boundaries as the populations that constitute communities are not congruent and rarely have persistent functional roles regulating the communities’ higher-level properties. Instead we should represent ecological communities indexically, by identifying ecological communities via the network of weak causal interactions between populations that unfurl from a starting set of populations. This precisification of ecological communities helps identify how community properties remain invariant, and why they have robust characteristics. This respects the (...) diversity and aggregational nature of these complex systems while still vindicating them as units worthy of investigation. (shrink)

Eric Katz in Zombie Arguments defends the thesis authenticity is indispensable to conservation. I agree. However, I argue authenticity appears in degrees and can be reclaimed by populations through their continuing evolutionary responses to the world. This means that interventions that diminish the value of a population through reducing their authenticity can be permitted in limited cases. When our actions retain the remaining authentic features in a threatened population we should allow such a diminishment as authenticity can be reclaimed in (...) time. (shrink)

Biodiversity is a key concept in the biological sciences. While it has its origin in conservation biology, it has become useful across multiple biological disciplines as a means to describe biological variation. It remains, however, unclear what particular biological units the concept refers to. There are currently multiple accounts of which biological features constitute biodiversity and how these are to be measured. In this paper, I draw from the species concept debate to argue for a set of desiderata for the (...) concept of “biodiversity” that is both principled and coheres with the concept’s use. Given these desiderata, this concept should be understood as referring to difference quantified in terms of the phylogenetic structure of lineages, also known as the ‘tree of life’. (shrink)

I will entertain and reject three arguments which putatively establish that the individuals produced through de-extinction ought to be the same species as the extinct population. Forms of these arguments have appeared previously in restoration ecology. The first is the weakest, the conceptual argument, that de-extinction will not be de-extinction if it does not re-create an extinct species. This is misguided as de-extinction technology is not unified by its aim to re-create extinct species but in its use of the remnants (...) of extinct populations as a resource. The second is the argument from authenticity; the populations produced by de-extinction technologies will be inauthentic if they are not of the extinct species and, therefore, will not be valuable. I argue authenticity is not required in conservation as the value of authenticity varies between people and cultures, and the novelty of de-extinct species will be equally desirable in many cases. The third argument is from retributive justice; we need the de-extinct population to have the same species identity as we owe a moral debt to the extinct population. I find the case for retributive justice unconvincing and argue that acting as if we have a duty to resurrect extinct species will result in a world with less species. Ultimately all the arguments that connect de-extinction technology to species identity fail, leaving us to consider a more complex calculus for the justification of de-extinction in conservation. (shrink)

If ecological systems are functionally organised, they can possess functions or malfunctions. Natural function would provide justification for conservationists to act for the protection of current ecological arrangements and control the presence of populations that create ecosystem malfunctions. Invasive species are often thought to be malfunctional for ecosystems, so functional arrangement would provide an objective reason for their control. Unfortunately for this prospect, I argue no theory of function, which can support such normative conclusions, can be applied to large scale (...) ecosystems. Instead ecological systems have causal structure, with small clusters of populations achieving functional arrangement. This, however, does not leave us without reason to control invasive species. We can look at the causal arrangement of ecological systems for populations that support ecological features that we should preserve. Populations that play a causal role in reducing biodiversity should be controlled, because biodiversity is a good all prudent agents should want to preserve. (shrink)

If ecological systems are functionally organised, they can possess functions or malfunctions. Natural function would provide justification for conservationists to act for the protection of current ecological arrangements and control the presence of populations that create ecosystem malfunctions. Invasive species are often thought to be malfunctional for ecosystems, so functional arrangement would provide an objective reason for their control. Unfortunately for this prospect, I argue no theory of function, which can support such normative conclusions, can be applied to large scale (...) ecosystems. Instead ecological systems have causal structure, with small clusters of populations achieving functional arrangement. This, however, does not leave us without reason to control invasive species. We can look at the causal arrangement of ecological systems for populations that support ecological features that we should preserve. Populations that play a causal role in reducing biodiversity should be controlled, because biodiversity is a good all prudent agents should want to preserve. (shrink)

The question of whether there are laws of nature in ecology has developed substantially in the last 20 years. Many have attempted to rehabilitate ecology’s lawlike status through establishing that ecology possesses laws that robustly appear across many different ecological systems. I argue that there is still something missing, which explains why so many have been skeptical of ecology’s lawlike status. Community ecology has struggled to establish what I call a General Unificatory Theory. The lack of a GUT causes problems (...) for explanation as there are no guidelines for how to integrate the lower-level mathematical and causal models into a larger theory of how ecological assemblages are formed. I turn to a promising modern attempt to provide a unified higher-level explanation in ecology, presented by ecologist Mark Vellend, and advocate for philosophical engagement with its prospects for aiding ecological explanation. (shrink)

The introduction of new genetic material into wild populations, using novel biotechnology, has the potential to fortify populations against existential threats, and, controversially, create wild genetically modified populations. The introduction of new genetic variation into populations, which will have an ongoing future in areas of conservation interest, complicates long-held values in conservation science and park management. I discuss and problematize, in light of genetic intervention, what I consider the three core goals of conservation science: biodiversity, ecosystem services, and wilderness. This (...) uneasy relationship, however, does not forgo the use of such interventions. I argue there is a case for the application of this technology within some interpretations of the moral frameworks of wilderness and biodiversity, despite apparent conflict between these values and the technology, and the possibility that this technology's use displays some limitations of the ecosystem services framework. Ultimately, the advent of biotechnology assisted restoration highlights the need for us to reevaluate our ethical concepts of conservation at times of global environmental and technological change. (shrink)

All known chimpanzee populations have been observed to hunt small mammals for meat. Detailed observations have shown, however, that hunting strategies differ considerably between populations, with some merely collecting prey that happens to pass by while others hunt in coordinated groups to chase fast-moving prey. Of all known populations, Taï chimpanzees exhibit the highest level of cooperation when hunting. Some of the group hunting roles require elaborate coordination with other hunters as well as precise anticipation of the movements of the (...) prey. The meat-sharing rules observed in this community guarantee the largest share of the meat to hunters who perform the most important roles leading to a capture. The learning time of such hunting roles is sometimes especially long. Taï chimpanzee males begin hunting monkeys at about age 10. The hunters’ progress in learning the more sophisticated hunting roles is clearly correlated with age; only after 20 years of practice are they able to perform them reliably. This lengthy learning period has also been shown in some hunter-gatherer societies and confirms the special challenge that hunting represents. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Gandhi's Hope: Learning from Other Religions as a Path to PeaceChristopher Key ChappleGandhi's Hope: Learning from Other Religions as a Path to Peace. By Jay McDaniel. Maryknoll, NY: Orbis Books, 2005. 134 + viii pp.This book by prominent Protestant theologian Jay McDaniel suggests that Mahatma Gandhi challenged the modern world by publicly revealing that which he learned from other faith traditions and advocating this path as a way (...) for intercultural understanding. The wisdom of Gandhi holds special poignancy today, when the processes of globalization and migration have placed followers of different faiths in closer proximity than can be remembered in the past five hundred years.Jay McDaniel writes with crisp clarity and organizes his insights into bite-sized pieces. He lays out five challenges that face all the world's faiths: compassion, self-criticism, simple living, ecological awareness, and welcoming religious diversity. In approaching this decidedly postmodern list of issues, McDaniel draws from two primary resources: the experiences shared by his students at Hendrix College and the writings of Alfred North Whitehead. Along the way, he invokes the Buddhist teacher and leader Thich Nhat Hanh and several progressive Catholics, including Sister Joan Chittester and theologians Hans Küng and Paul Knitter.Continuing with a style developed in his earlier books, McDaniel latches onto a [End Page 237] metaphor and extends it to illustrate his central point—in this case, the value of diversity. In past books, he has used the image of the hunter and the hunted to underscore the need to respect animals. In Gandhi's Hope, the metaphor he employs is that of a jazz concert, with all different manner of instruments pooling their resources to create a tapestry of diverse yet harmonious music.Although the title of the book may seem to indicate that Gandhi will serve as thefocus, in fact, Whitehead anchors McDaniel's approach. Through an updated approach to Whitehead, McDaniel seeks to answer the questions regarding diversity and compassion that he has posed. He suggests that an experience of concrescence will result in the sort of heightened awareness needed to increase one's conscience and to make the ethical changes needed to respond to the current state of the world. McDaniel identifies twelve "planks" that will usher Whitehead's vision into the contemporary world. These twelve aspects seem also to be heavily influenced by McDaniel's own encounter with Buddhism: interdependence, impermanence, indeterminism, mind/matter, deep listening, value, God, creativity, persuasive power, divine empathy, many forms of salvation, and life after death. These broad categories embrace key notions found in all religious traditions. Some traditions emphasize certain aspects more than others. Buddhists cleave to impermanence and Jews to establishing a covenant with God, but Jews also recognize that all things will pass, and Buddhists revere their great teacher and many strive to emulate his experience through techniques akin to those who worship God.In order for religious traditions to maintain their urgency and relevance, McDaniel suggests that they must respond actively to the looming threat of environmental degradation. Consumer culture drives people into a state of indifference about natural resources, and arrogance prevents people from taking an interest in the life patterns and cultures of others. These tendencies lie at the root of the world's troubles. McDaniel suggests that process theology can remedy these ills by calling people into a state of compassion and can help guide people toward adopting thoughtful self-criticism, to living a more simple life, to recognizing the importance of other living beings and ecosystems, and to celebrating diversity of cultures. Echoing a refrain long associated with process thought, McDaniel writes "the universe is a creative and creating process of interdependent events, lured by but not controlled by God, such that the future is not yet decided, not even by God" (p. 71). To the extent that religions sustain themselves by reinforcing separateness and promoting a narrow cultural identity and/or an unthinking fundamentalism, they can be an impediment to peace, which, for McDaniel, is an important goal of the world's religions.When attempting to theologize about ultimate matters, McDaniel posits "four faces of the sacred," which he lists as the Abyss... (shrink)

Proponents of the standard evolutionary biology paradigm explain human “altruism” in terms of either nepotism or strict reciprocity. On that basis our underlying nature is reduced to a function of inclusive fitness: human nature has to be totally selfish or nepotistic. Proposed here are three possible paths to giving costly aid to nonrelatives, paths that are controversial because they involve assumed pleiotropic effects or group selection. One path is pleiotropic subsidies that help to extend nepotistic helping behavior from close family (...) to nonrelatives. Another is “warfare”—if and only if warfare recurred in the Paleolithic. The third and most plausible hypothesis is based on the morally based egalitarian syndrome of prehistoric hunter-gatherers, which reduced phenotypic variation at the within-group level, increased it at the between-group level, and drastically curtailed the advantages of free riders. In an analysis consistent with the fundamental tenets of evolutionary biology, these three paths are evaluated as explanations for the evolutionary development of a rather complicated human social nature. (shrink)

Children may be viewed as public goods whereby both parents receive equal genetic benefits yet one parent often invests more heavily than the other. We introduce a microeconomic framework for understanding household investment decisions to address questions concerning conflicts of interest over types and amount of work effort among married men and women. Although gains and costs of marriage may not be spread equally among marriage partners, marriage is still a favorable, efficient outcome under a wide range of conditions. This (...) bioeconomic framework subsumes both cooperative and conflictive views on the sexual division of labor. We test hypotheses concerning marriage markets, assortative mating, and men’s labor motivations among Tsimane forager-horticulturalists of Bolivia and find that: (1) men and women both value work effort in marital partners, (2) marital labor contributions are complementary, (3) work effort is correlated between spouses, (4) total production is correlated with total reproduction, and (5) better hunters have higher fitness gains within marital unions. (shrink)

Eric G. Forbes, Lesley Murdin, & Frances Willmoth, volume 2, 1682–1703, volume 3, 1703–1719; Institute of Physics Publishing, Bristol & Philadephia, 1997, 2002, pp. xlvii+1095, lxvi+1038, Price £199 each hardback, ISBN 0-7503-0391-3, 0-7503-0763-3The correspondence of John Wallis, volume 1 Philip Beeley, & Christoph J. Scriba, with the assistance of Uwe Mayer and Siegmund Probst; Oxford University Press, Oxford, 2003, pp. xlvii+651, Price £120 hardback, ISBN 0-19-851066-7 The Hartlib Papers. Second edition. A complete text and image database of the papers of (...) Samuel Hartlib HROnline, Sheffield, 2 CDs, Price £1,500, ISBN 0-9542608-0-5The Letters of Jan Jonston to Samuel HartlibW. J. Hitchens, Adam Matruszewski, & John Young ; Retro-Art, Warsaw, 2000, pp. 269, Price £25 paperback, ISBN 83-87992-12-7. (shrink)

With a new reading of Thomas Reid on primary and secondary qualities, Christopher A. Shrock illuminates the Common Sense theory of perception. Shrock follow's Reid's lead in defending common sense philosophy against the problem of secondary qualities, which claims that our perceptions are only experiences in our brains, not of the world.

ABSTRACTEmotions influence cognitive processes involved in memory. While some research has suggested that cognitive scope is determined by affective valence, recent models of emotion–cognition interactions suggest that motivational intensity, rather than valence, influences these processes. The present research was designed to clarify how negative affects differing in motivational intensity impact memory for centrally or peripherally presented information. Experiments 1 & 2 found that, relative to a neutral condition, high intensity negative affect enhances memory for centrally presented information. Experiment 3 replicated (...) this effect using another high intensity negative affect. Experiment 4 extended this by finding that, relative to a neutral condition, low intensity negative affect enhanced memory for peripherally presented information. Finally, in Experiment 5, the effects of sadness and threat on scope of memory were directly compared, finding that threat narrowed scope of... (shrink)

Although populism is an ideologically fluid political vehicle, it is not one that is intrinsically anti-business. Indeed, different varieties of populist parties may encourage business activity for utilitarian ends, but with their own ideas on what businesses should be doing. This reality implies that initiatives not related to national greatness or priorities as defined by the populist leadership may be viewed as redundant. Key among such initiatives would be corporate social responsibility (CSR). In a populist environment, it is possible that (...) firms may divert resources away from broad-based CSR under pressure from populist governments. This article explores the relationship between populist governance and CSR with an econometric examination of over a thousand firms in 13 countries under both pro- and anti-business populist governments at varying times from 2012 to 2020. Using dynamic panel data methods, we find strong evidence that firms substitute away significantly from CSR under populism. This effect grows significantly larger under anti-business populists. (shrink)

In the quantum-Bayesian approach to quantum foundations, a quantum state is viewed as an expression of an agent’s personalist Bayesian degrees of belief, or probabilities, concerning the results of measurements. These probabilities obey the usual probability rules as required by Dutch-book coherence, but quantum mechanics imposes additional constraints upon them. In this paper, we explore the question of deriving the structure of quantum-state space from a set of assumptions in the spirit of quantum Bayesianism. The starting point is the representation (...) of quantum states induced by a symmetric informationally complete measurement or SIC. In this representation, the Born rule takes the form of a particularly simple modification of the law of total probability. We show how to derive key features of quantum-state space from (i) the requirement that the Born rule arises as a simple modification of the law of total probability and (ii) a limited number of additional assumptions of a strong Bayesian flavor. (shrink)

Thomas Reid often seems distant from other Scottish Enlightenment figures. While Hume, Hutcheson, Kames, and Smith wrestled with the nature of social progress, Reid was busy with natural philosophy and epistemology, stubbornly loyal to traditional religion and ethics, and out of touch with the heart of his own intellectual world. Or was he? I contend that Reid not only engaged the Scottish Enlightenment's concern for improvement, but, as a leading interpreter of Isaac Newton and Francis Bacon, he also developed a (...) scheme to explain the progress of human knowledge. Pulling thoughts from across Reid's corpus, I identify four key features that Reid uses to distinguish mature sciences from prescientific arts and inquiries. Then, I compare and contrast this scheme with that of Thomas Kuhn in order to highlight the plausibility and originality of Reid's work. (shrink)

In this article, we examine the advantages of simple metacognitive capabilities in a repeated social dilemma. Two types of metacognitive agent were developed and compared with a non-metacognitive agent and two fixed-strategy agents. The first type of metacognitive agent takes the perspective of the opponent to anticipate the opponent's future actions and respond accordingly. The other metacognitive agent predicts the opponent's next move based on the previous moves of the agent and the opponent. The modeler agent achieves better individual outcomes (...) than a non-metacognitive agent and is more successful at encouraging cooperation. The opponent-perspective agent, by contrast, fails to achieve these outcomes because it lacks important information about the opponent. These simple agents provide insights regarding modeling of metacognition in more complex tasks. (shrink)

There is a growing consensus among philosophers that hope is a moral virtue: the virtuously hopeful person experiences the right amount of hope for the right things. This moralization of hope presents us with a puzzle. The historical consensus is that hope is a passion and hope is a theological virtue, not a moral virtue. Thomas Aquinas, the philosopher who wrote most extensively on hope, offers an explanation for why hope is not a moral virtue. The aim of this paper (...) is argue that Aquinas is right in thinking that hope is not a moral virtue.1. (shrink)

Une gemme en agate peu étudiée provenant d’Anapa, datée de la période impériale, présente un grand intérêt, dans la mesure où elle diffère de la plupart des gemmes magiques par sa forme sphérique, sa grande taille et son contenu : elle commence par une référence aux rituels traditionnels grecs d’expulsion et se termine par une liste des parties de la tête humaine semblable à celle que l’on trouve dans un manuel médical hippocratique. La gemme ne serait pas une amulette, comme (...) les éditeurs précédents l’ont supposé, mais plutôt un manuel miniature contenant des instructions pour la fabrication d’amulettes. (shrink)

Facial blushing involves a reddening of the face elicited in situations involving unwanted social attention. Such situations include being caught committing a social transgression, which is typical...

The method of Conceptual Analysis makes use of natural language speaker intuitions about the meanings of expressions, and relies on an externalist assumption about meanings—namely, that they can be given in terms of referential relations and truth. This article argues that this widely used methodology in metaphysics is troubled, because the assumed externalist hypothesis about natural language meanings is beset with trenchant obstacles in explaining linguistic phenomena. It argues that the use of Conceptual Analysis in metaphysical investigation inherits the difficulties (...) for the externalist hypothesis generally assumed by metaphysical inquiry. It explores two cases of such investigation that serve to exemplify the breadth of topics susceptible to troubles with the externalist hypothesis regarding natural language meanings: the extended mind hypothesis and the metaphysics of causation. (shrink)

Metaphysical investigation often proceeds by way of linguistic meaning. This tradition relies on an assumption about meanings, namely that they can be given in terms of referential relations and truth. Chomsky and others have illustrated the difficulty with this externalist hypothesis regarding natural language meanings, which implies that natural languages are ill‐suited for the purposes of metaphysical investigation. In reply to this discordance between the features of natural languages and the goals of metaphysical investigation, metaphysicians propose that we look to (...) the invented languages used to express our best scientific theories as metaphysical guides, in the hope that these languages are better behaved. I argue that this retreat is beset with similar troubles for the metaphysician. In particular, I argue that central terms in the field of biology, namely ‘gene’ and ‘species’, exhibit a kind of lexical flexibility that renders them, much like their natural language counterparts, ill‐suited for the metaphysician's aims. (shrink)